Adding to the Agricultural Toolkit: Next generation auxins and anti-auxins
Aims and objectives: This proposal describes a set of experiments that allows us to specify and quantify the changes between members of the receptor family. In turn, this allows us to describe the special features on each type of auxin which determine specificity and allows us to start to understand the molecular rules defining this specificity. Auxins are also valuable agrochemicals. In their main application as herbicides they already present a certain element of selectivity, killing broad-leaved weeds in preference to cereals. However, we now know that there are more layers of selectivity to be exploited. This makes it imperative that we learn much more detail about the rules of specificity if we are to design a new generation of selective plant growth regulators.
Our project sets out a number of complimentary lines of experimentation to investigate in great detail the features which differentiate AFB5, for example, from TIR1. We will use the latest biophysical techniques to measure the speeds of binding and the energy changes on binding. By comparing these values and comparing them with computer-driven calculations of the auxin molecules themselves, we will be able to derive design features specific for each template. We will develop a matrix of detailed information about what makes a molecule an auxin, and how they are selective, and we will use this as a platform for designing new auxins and anti-auxins.
Potential applications and benefits: Examples of agricultural uses of auxins include treatments to flowers, fruits and nuts, but primarily as selective weedkillers to kill broadleaved plants, not cereals and grasses. Auxins as agrochemicals have high commerical value and are imperative if we are to sustain global food security. This project will measure in fine detail the very special interactions made by auxins at their several, but specific target sites. From this information we will start to define rules for new and more selective auxinic agrochemicals. The aim is to create a new generation of safe, selective and low dosage agricultural compounds.
Document Type: Research Article
Publication date: 01 September 2017
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