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Evaluation of a New Hemostatic Agent in a Porcine Grade V Liver Injury Model

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Abstract:

Our objective was to evaluate the hemostatic efficacy of a newly modified chitosan in a porcine grade V liver injury model. Fifteen Yorkshire pigs underwent standardized grade V liver injuries with a specially designed liver clamp and were randomized to either modified chitosan (MC) patch treatment or standard gauze packing. Free bleeding was allowed for 30 seconds. Fluid resuscitation was infused as necessary to reestablish a mean arterial pressure (MAP) within at least 80 per cent of the preinjury MAP. Animals were observed for 90 minutes or until death. Endpoints were survival, total blood loss, time to hemostasis, and resuscitation MAP, and resuscitation volume. Total mean blood loss was less in the MC patch group (464 ± 267 mL vs 1234 ± 78 mL, P < 0.001). Time to hemostasis was significantly less (4.8 ± 2.5 minutes in the MC patch group vs 9.6 ± 2.5 minutes, P < 0.01). Fluid resuscitation was less (1098 ± 459 mL in the MC patch group vs 1770 ± 172 mL, P < 0.01). Survival was 100 per cent in the MC patch group and 80 per cent in the gauze packing group. MC patches demonstrate the continued hemostatic agent evolution for improved control of lethal solid organ bleeding.

Document Type: Research Article

Affiliations: Division of Clinical and Outcomes Research, Department of Surgery, R. Adams Cowley Shock Trauma Center, Baltimore, Maryland, USA

Publication date: March 1, 2010

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  • The Southeastern Surgical Congress owns and publishes The American Surgeon monthly. It is the official journal of the Congress and the Southern California Chapter of the American College of Surgeons, which all members receive each month. The journal brings up to date clinical advances in surgical knowledge in a popular reference format. In addition to publishing papers presented at the annual meetings of the associated organizations, the journal publishes selected unsolicited manuscripts. If you have a manuscript you'd like to see published in The American Surgeon select "Information for Authors" from the Related Information options below. A Copyright Release Form must accompany all manuscripts submitted.
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