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Open Access Exploring Modular Glycolipids Involved in Nematode Chemical Communication

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This article is Open Access under the terms of the Creative Commons CC BY-NC-ND licence.

Chemical communication in nematodes has been known for over half a century, but the underlying molecular basis remained largely elusive. Recent advances in analytical techniques facilitated the characterization of a modular glycolipid library based on the dideoxysugar L-ascarylose, which modulates behavior and development in the model organism C. elegans. Ascaroside signaling is highly conserved in nematodes and represents a key factor in nematode chemical ecology. Ascaroside biosynthesis depends on the co-option of the peroxisomal β-oxidation cycle and in addition integrates a large diversity of additional building blocks derived from various primary metabolic pathways to give rise to species-specific modular assemblies, thus, transcending the concept of strictly segregated primary versus secondary metabolism.
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Keywords: ASCAROSIDES; CHEMICAL ECOLOGY; GLYCOLIPIDS; MODULAR METABOLITES; NEMATODES

Document Type: Research Article

Affiliations: Laboratory for Bioanalytical Chemistry University of Neuch√Ętel Avenue de Bellevaux 51, Neuch√Ętel, Switzerland;, Email: [email protected]

Publication date: 01 May 2018

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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