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Open Access Ultrafast Fluorescence Dynamics in Flurbiprofen–Amino Acid Dyads and in the Supramolecular Drug/Protein Complex

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The interaction dynamics between the drug flurbiprofen (FBP) and human serum albumin (HSA) has been investigated by time-resolved fluorescence spectroscopy, combining femtosecond fluorescence upconversion and picosecond time-correlated single photon counting. In order to obtain additional information on the drug/ protein interaction, several covalently linked model dyads, composed of FBP and tryptophan or tyrosine, were also studied. For all systems, the main feature was a remarkable dynamic FBP fluorescence quenching, more prominent in the dyads than in the protein complex. All systems also displayed a clear stereoselectivity depending on the (S)- or (R)-form of FBP, that was strongly influenced by the conformational arrangement of the investigated chromophores.

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Keywords: DRUG/PROTEIN BINDING; FLUORESCENCE UPCONVERSION; FLURBIPROFEN; HUMAN SERUM ALBUMIN; TIME-CORRELATED SINGLE PHOTON COUNTING; TIME-RESOLVED FLUORESCENCE; TRYPTOPHAN; TYROSINE

Document Type: Research Article

Affiliations: 1: Departamento de Química/Instituto de Tecnología, Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n, 46022 Valencia, Spain, School of Chemistry, University of East Anglia, Norwich Research Park NR4 7TJ, Norwich, United Kingdom;, Email: [email protected] 2: Departamento de Química/Instituto de Tecnología, Química UPV-CSIC, Universitat Politècnica de València Camino de Vera s/n, 46022 Valencia, Spain 3: LIDYL, Laboratoire Interactions, Dynamiques et Lasers CEA, CNRS, Université Paris-Saclay, CEA Saclay 91191 Gif-sur-Yvette, France 4: LIDYL, Laboratoire Interactions, Dynamiques et Lasers CEA, CNRS, Université Paris-Saclay, CEA Saclay 91191 Gif-sur-Yvette, France;, Email: [email protected]

Publication date: 01 February 2017

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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