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Open Access Divergent Reaction Mechanisms in the Aminofluorination of Alkenes

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The aminofluorination of alkenes has become an attractive platform for the synthesis of β-amino-fluorinated compounds, valuable building blocks in medicinal and agricultural chemistry. The novel methodologies disclosed in recent years have unraveled a broad array of reaction mechanisms, so that the interest in these transformations transcends the mere synthetic aspects. This review aims to summarize the most relevant findings in this area attending at the nature of the fluorine source, and thus the specific mechanism operating in each of these transformations, namely electrophilic, nucleophilic, radical, and late transition metal-catalyzed reactions.

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Keywords: ALKENES; AMINOFLUORINATION; DIFUNCTIONALIZATION

Document Type: Research Article

Affiliations: 1: University of Zürich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland 2: University of Zürich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zürich,,, Switzerland. [email protected]

Publication date: 2014-06-01

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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