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Open Access NMR Spectroscopy: An Excellent Tool to Understand RNA and Carbohydrate Recognition by Proteins

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Structural biology plays a key role in understanding how networks of protein interactions with their partners are organized at the atomic level. In this review, we show that NMR is a very efficient method to solve 3D structures of protein – RNA and protein–carbohydrate complexes of high quality. We explain the importance of studying such interactions and describe the main steps that are required to determine structures of these types of complexes by NMR. Finally, we show that X-ray crystallography and NMR are complementary methods and briefly report on advantages and disadvantages of each approach.

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Keywords: NMR SPECTROSCOPY; PROTEIN STRUCTURE; PROTEIN–CARBOHYDRATE COMPLEX; PROTEIN–RNA COMPLEX; SPECIFIC INTERACTION

Document Type: Research Article

Affiliations: 1: Institute for Molecular Biology and Biophysics ETH Zürich CH-8093 Zürich, Switzerland 2: Institute for Molecular Biology and Biophysics ETH Zürich CH-8093 Zürich, Switzerland. [email protected] 3: Institute for Molecular Biology and Biophysics ETH Zürich CH-8093 Zürich, Switzerland. [email protected]

Publication date: 01 October 2012

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  • International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

    CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.

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