Artificial Metalloenzymes for Enantioselective Catalysis Based on the Biotin-Avidin Technology

Authors: Mao, Jincheng; Ward, Thomas R.

Source: CHIMIA International Journal for Chemistry, Volume 62, Number 12, December 2008 , pp. 956-961(6)

Publisher: Swiss Chemical Society

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Abstract:

Artificial metalloenzymes, based on the incorporation of a biotinylated catalytically active organometallic moiety within streptavidin, offer an attractive alternative to homogeneous, heterogeneous and enzymatic catalysis. In this account, we outline our recent results and implications in the developments of such artificial metalloenzymes for various asymmetric transformations, including hydrogenation, transfer hydrogenation, allylic alkylation and sulfoxidation.

Keywords: ARTIFICIAL METALLOENZYMES; ASYMMETRIC CATALYSIS; BIOTIN-(STREPT)AVIDIN TECHNOLOGY; ENANTIOSELECTIVITY

Document Type: Research article

DOI: 10.2533/chimia.2008.956

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