Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development

Authors: Hamann, Mark T.¹; Hill, Russell²; Roggo, Silvio³

Source: CHIMIA International Journal for Chemistry, Volume 61, Number 6, June 2007 , pp. 313-321(9)

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Abstract:

Over a half century has passed since the first discovery of spongothymidine and spongouridine. These sponge-derived natural products initiated a chain of events that has resulted in countless lives saved from viral infections and cancer. In addition these humble marine products inspired the critical evaluation of marine life for the production of novel chemistry and new drug leads. The resulting natural products chemistry from these efforts is unprecedented in regard to structural complexity and biological activity. The drug leads based on marine natural products have however created unique challenges in scaleable production and structural optimization to evaluate toxicity and enhance biological activity. In this report we have focused our discussion on the progress toward the development of general methodologies for the production, optimization and development of rare but promising marine natural product drug leads. Key developments discussed briefly include sourcing, lead optimization, molecular biology and phylogeny, marine microbial culture, and tools for structure assignment.

Keywords: ALKALOIDS; MARINE NATURAL PRODUCTS; PEPTIDES; POLYKETIDES; TERPENOIDS

Document Type: Research article

DOI: http://dx.doi.org/10.2533/chimia.2007.313

Affiliations: 1: Tel.: 1 662 915 5730, Departments of Pharmacognosy, Pharmacology, Chemistry and Biochemistry and the National Center for the Development of Natural Products (NCNPR), School of Pharmacy, The University of Mississippi, University, MS 38677, USA, Tr 2: The Center of Marine Biotechnology, The University of Maryland Biotechnology Institute, Baltimore MD, USA, Triton BioPharma Oxford, Mississippi, USA 3: Novartis Institutes for BioMedical Research, Natural Products Unit, Novartis Pharma AG, CH-4002 Basel

Publication date: 2007-06-01

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International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.
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Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development

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