Encoded Self-Assembling Chemical Libraries

Authors: Melkko, Samu; Sobek, Jens; Guarda, Greta; Scheuermann, Jörg; Dumelin, Christoph E.; Neri, Dario

Source: CHIMIA International Journal for Chemistry, Volume 59, Number 11, November 2005 , pp. 798-802(5)

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Abstract:

The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-assembly of large chemical libraries in which every chemical moiety is associated to a unique DNA sequence, serving as an 'identification bar code'. In this article, we describe the principles, the potential, and the challenges of this novel technology, which promises to facilitate the isolation of high-affinity binders to protein targets of biological and pharmaceutical interest.

Keywords: AFFINITY MATURATION; COMBINATORIAL CHEMISTRY; DNA-TEMPLATED CHEMISTRY; ENCODED SELF-ASSEMBLING CHEMICAL LIBRARIES; LEAD IDENTIFICATION

Document Type: Research article

DOI: http://dx.doi.org/10.2533/000942905777675525

Publication date: 2005-11-01

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International Journal for Chemistry and Official Membership Journal of the Swiss Chemical Society (SCS) and its Divisions

CHIMIA, a scientific journal for chemistry in the broadest sense, is published 10 times a year and covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.
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