Functional Brain Receptor Imaging with Positron Emission Tomography

Authors: Ametamey, Simon M.; Westera, Gerrit; Gucker, Pascale; Schönbächler, Roland; Honer, Michael; Spang, Jörg E.; Schubiger, P. August

Source: CHIMIA International Journal for Chemistry, Volume 54, Number 11, November 2000 , pp. 622-626(5)

Publisher: Swiss Chemical Society

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

A new cocaine derivative for imaging the dopamine transporter has been developed. Measurements of radioligand binding of 11C-(+)-McN-5652 in vivo with PET suggests that ecstasy interacts directly with the serotonin reuptake sites and that a single oral dose of ecstasy (1.5 mg/kg) does not cause any changes in the serotonin transporter density in the human brain. Finally, a number of epibatidine derivatives have been developed as ligands to study the central nAChRs in vivo, however, toxicity studies prevented further clinical use.

Keywords: DOPAMINE AND SEROTONIN TRANSPORTERS; ECSTASY; EPIBATIDINE; PET; PHARMACEUTICAL CHEMISTRY

Document Type: Research article

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$28.00 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A