Microchannel-Based Surface-Enhanced Raman Spectroscopy for Integrated Microfluidic Analysis
Source: Applied Spectroscopy
Publisher: Society for Applied Spectroscopy
Chun-hong Lai, Li Chen, Gang Chen, Yi Xu, Chun-yan Wang
We have demonstrated a microchannel-based surface-enhanced Raman spectroscopy (SERS) sensing approach for integrated microfluidic analysis developed using standard micro-fabrication technology. Our approach allows high-sensitivity SERS sensing with a comparatively lowexcitation optical power intensity and large cross-sectional microchannel for biological cell analysis. Utilizing a microchannel with a cross section of 100 x 70 μm2, we achieved a detection limit smaller than 50 nM for rhodamine 6G at an excitation power intensity of 132 W/cm2, avoiding any possible heating effects on the sample under investigation. There is great potential for further improvement in the sensitivity of this microchannel-based SERS detection.
Index Headings: Surface-enhanced Raman spectroscopy; Integrated microchannel; Micro-fluid.
Appeared or available online: January 1, 2014