Microchannel-Based Surface-Enhanced Raman Spectroscopy for Integrated Microfluidic Analysis

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Abstract:

We have demonstrated a microchannel-based, surface-enhanced Raman spectroscopy (SERS) sensing approach for integrated microfluidic analysis developed using standard micro-fabrication technology. Our approach allows high-sensitivity SERS sensing with a comparatively low-excitation optical power intensity and large cross-sectional microchannel for biological cell analysis. Utilizing a microchannel with a cross section of 100 × 70 μm2, we achieved a detection limit smaller than 10 nM for rhodamine 6G at an excitation power intensity of 132 W/cm2, avoiding any possible heating effects on the sample under investigation. There is great potential for further improvement in the sensitivity of this microchannel-based SERS detection.

Keywords: Integrated microchannel; Micro-fluid; Surface-enhanced Raman spectroscopy

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/13-07146

Publication date: January 1, 2014

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