Sensitivity-Enhanced Transmission Raman Spectroscopy

Author: Pelletier, Michael J.

Source: Applied Spectroscopy, Volume 67, Issue 8, Pages 204A-220A and 813-996 (August 2013) , pp. 829-840(12)

Publisher: Society for Applied Spectroscopy

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Transmission Raman sensitivity for a representative commercial pharmaceutical tablet was increased by a factor of 40 using optics that returned lost laser and Raman photons to the tablet surface. A new achromatic one-way mirror is introduced that uses the spatial coherence of laser light to nondestructively force laser photons through the reflective tablet coating. Transmission Raman mapping and spatially offset Raman spectroscopy (SORS) mapping were developed and used to better understand the sensitivity-enhancement technology. Fundamental limitations of the sensitivity-enhancement approach are described and used to guide the design of the optics. The sensitivity-enhancement optics are compatible with commercial transmission Raman instruments.

Keywords: Enhanced sensitivity; SORS mapping; Spatially offset Raman spectroscopy; Transmission Raman; Transmission Raman mapping

Document Type: Research Article


Affiliations: Pfizer Worldwide Research and Development, Analytical Technology, Pharmaceutical Sciences, 445 Eastern Point Road, Groton, CT 06340 USA

Publication date: August 1, 2013

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