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Chemiluminescent Identification and Quantification of Artemisinin and Relevant Sesquiterpene Lactone Derivatives

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Abstract:

A simple, sensitive, and rapid chemiluminescence method was developed for the detection and quantification of selected derivatives of artemisinin. It was found that the chemiluminescence (CL) signal resulting from the alkaline luminol reaction of the artemisinin derivatives in the presence of hematin was linear over a wide concentration range. We report results that suggest that a visual test or a test involving digital image capture may be used in addition to a field-ready instrumental approach to combat drug counterfeiting of malarial therapies.

Keywords: Artemisinin; Chemiluminescence; Counterfeit Medication

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/11-06462

Affiliations: 1: Department of Chemistry, 501 East Saint Joseph Street, South Dakota School of Mines and Technology, Rapid City, South Dakota 57701, USA 2: Department Information Technology Services, 501 East Saint Joseph Street, South Dakota School of Mines and Technology, Rapid City, South Dakota 57701, USA 3: Department of Pathology and Laboratory Medicine, 1425 Portland Ave., Rochester General Hospital, Rochester, New York 14621, USA 4: and Department of Chemistry, 85 Lomb Memorial Drive, Rochester Institute of Technology, Rochester, New York 14623, USA

Publication date: February 1, 2012

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