Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS)

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Abstract:

Eighty drugs of abuse and metabolites were successfully measured by surface-enhanced Raman spectroscopy (SERS) using gold- and silver-doped sol-gels immobilized in glass capillaries. A method was developed that provided consistent detection of 50 ppb cocaine in saliva in a focused study. This general method was successfully applied to the detection of a number of additional drugs in saliva, such as amphetamine, diazepam, and methadone.

Keywords: DRUGS OF ABUSE; SALIVA; SERS; SURFACE-ENHANCED RAMAN SPECTROSCOPY

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/11-06310

Affiliations: 1: Real-Time Analyzers, Inc., 362 Industrial Park Rd #8, Middletown, Connecticut 06457, USA 2: Real-Time Analyzers, Inc., 362 Industrial Park Rd #8, Middletown, Connecticut 06457, USA. stu@RTA.biz

Publication date: September 1, 2011

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