Near-Infrared Chemical Imaging Slope as a New Method to Study Tablet Compaction and Tablet Relaxation

$29.00 plus tax (Refund Policy)

Buy Article:

Abstract:

Near-infrared chemical imaging (NIR-CI) spectra of lactose monohydrate tablets were acquired and the spectral slope from each pixel in the data hypercube was used to assess tablet compaction and relaxation. Tablets were prepared at compaction pressures of 100, 300, and 500 MPa using un-lubricated and magnesium stearate lubricated lactose monohydrate. Results show that NIR slope distribution is a function of applied compaction forces and magnesium stearate lubrication. The distribution of NIR slope values was studied using histograms and statistical parameters. The mean slope value yields a linear calibration curve that predicts tablet compaction pressure as a function of spectral slope. The NIR-CI slope measurements were also used to study tablet relaxation, which occurs as tablets release some of the stored energy from compression. The NIR-CI slope method provides a qualitative description of the relaxation process and provides quantitative information describing relaxation through time.

Keywords: DIFFUSE REFLECTION; LIGHT SCATTERING; NEAR-INFRARED CHEMICAL IMAGING; NEAR-INFRARED SPECTROSCOPY; NIR-CI; PHARMACEUTICALS; POROSITY; POWDER TECHNOLOGY; TABLET COMPACTION

Document Type: Short Communication

DOI: http://dx.doi.org/10.1366/410-06078

Affiliations: 1: Department of Chemistry, University of Puerto Rico, Mayagü ez Campus, P.O. Box 9000, Mayagü ez 00681-9000, Puerto Rico 2: Environmental and Chemistry Group, Campus of Piedra de Bolívar, University of Cartagena, Cartagena, Colombia 3: Department of Chemistry, University of Puerto Rico, Mayagü ez Campus, P.O. Box 9000, Mayagü ez 00681-9000, Puerto Rico. rodolfoj.romanach@upr.edu

Publication date: April 1, 2011

More about this publication?
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more