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Fluorescent and Ultraviolet–Visible Spectroscopy Studies on the Antioxidation and DNA Binding Properties of Binuclear Tb(III) Complexes

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Abstract:

Tb(III) complexes were prepared from Tb(NO3)3·6H2O and four Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxaldehyde with aroylhydrazines. X-ray crystal and other structural analyses indicate that Tb(III) and every ligand can form a binuclear Tb(III) complex with 1:1 metal-to-ligand stoichiometry and nine-coordination at the Tb(III) center. Viscosity titration experiments and fluorescent and ultraviolet–visible (UV-Vis) spectroscopy results indicate that all the Tb(III) complexes can bind to Calf thymus DNA through intercalation with the binding constants at the order of magnitude of 106–107 M–1, and they may be used as potential anticancer drugs, but complexes containing active phenolic hydroxy groups may have stronger antitumor activities. Antioxidation results indicate that all the Tb(III) complexes have strong abilities of scavenging hydroxyl radicals and superoxide radicals, but complexes containing active phenolic hydroxy groups show stronger scavenging effects on hydroxyl radicals and complexes containing N-heteroaromatic substituent show stronger scavenging effects on superoxide radicals. However, Tb(III) emission with these systems is not observed, for these ligands rather are quenchers and unable to sensitize this metal ion.

Keywords: ANTIOXIDATION; CALF THYMUS DNA BINDING; FLUORESCENCE SPECTROSCOPY; RARE EARTH; TB3+ IONS: SCHIFF BASE; ULTRAVIOLET–VISIBLE SPECTROSCOPY; X-RAY CRYSTALLOGRAPHY

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370210792434260

Affiliations: 1: College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, P. R. China; College of Chemistry and Chemical Engineering, Key Laboratory of Longdong Biological Resources in Gansu Province, Longdong University, 745000 Qingyang, Gansu, P. R. China 2: College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, P. R. China 3: College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, P. R. China. yangzy@lzu.edu.cn 4: College of Chemistry and Chemical Engineering, Key Laboratory of Longdong Biological Resources in Gansu Province, Longdong University, 745000 Qingyang, Gansu, P. R. China

Publication date: September 1, 2010

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