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Surface-Enhanced Raman Scattering of Rat Tissues

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Abstract:

Surface-enhanced Raman scattering (SERS) is proven to be a powerful tool for investigation of biological structures. In this study, tissues obtained from different rat organs are examined using SERS. The tissue samples are crushed with a pestle after sudden freezing in liquid nitrogen and mixed with a concentrated colloidal silver nanoparticle suspension. The reproducibility of SERS spectra acquired from several tissue samples from different organs is demonstrated. The collected spectra are comparatively evaluated based on the physiological function of the organ from which the tissue is obtained. The spectra from the tissues show significant differences and indicate that they can be used for tissue characterization and differentiation. The identification of the origins of the bands on the spectra is also attempted. This study suggests that SERS can be used to monitor the changes at the molecular level during metabolic changes in an organ or tissue as a result of a disease or another cause.

Keywords: DIFFERENTIATION; DISEASE; SERS; SILVER NANOPARTICLES; SURFACE-ENHANCED RAMAN SCATTERING; TISSUE

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370209788559647

Affiliations: 1: Yeditepe University, Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, 34755 Kayisdagi-Istanbul, Turkey 2: Yeditepe University, Medical School, Department of Physiology, 34755 Kayisdagi-Istanbul, Turkey

Publication date: June 1, 2009

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