@article {Andanson:2009:0003-7028:512, author = "Andanson, Jean-Michel and Chan, K. L. Andrew and Kazarian, Sergei G.", title = "High-Throughput Spectroscopic Imaging Applied to Permeation Through the Skin", journal = "Applied Spectroscopy", volume = "63", number = "5", year = "2009", abstract = "Infrared (IR) spectroscopy has been successfully applied to study the permeation of substances through human skin in a high-throughput manner. The sample of skin was placed on the measuring surface of an attenuated total reflection (ATR) crystal and was divided into several areas. These areas were separated using a specially designed grid created on the surface of the skin and each area was subjected to a different combination of permeant and enhancer. ATR Fourier transform infrared (FT-IR) imaging was applied to measure the permeation of 12 liquid samples through a piece of skin smaller than 5 cm2. This work demonstrated that, using the ATR-FT-IR imaging method, it is possible to measure and directly compare the transdermal processes of several permeants under identical conditions.", pages = "512-517", url = "http://www.ingentaconnect.com/content/sas/sas/2009/00000063/00000005/art00009", doi = "doi:10.1366/000370209788347011", keyword = "HIGH THROUGHPUT, DRUGS, HUMAN SKIN, DIFFUSION, STRATUM CORNEUM, IMAGING, ATTENUATED TOTAL REFLECTION, FOURIER TRANSFORM INFRARED SPECTROSCOPY, ATR-FT-IR IMAGING" }