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High-Throughput Spectroscopic Imaging Applied to Permeation Through the Skin

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Abstract:

Infrared (IR) spectroscopy has been successfully applied to study the permeation of substances through human skin in a high-throughput manner. The sample of skin was placed on the measuring surface of an attenuated total reflection (ATR) crystal and was divided into several areas. These areas were separated using a specially designed grid created on the surface of the skin and each area was subjected to a different combination of permeant and enhancer. ATR Fourier transform infrared (FT-IR) imaging was applied to measure the permeation of 12 liquid samples through a piece of skin smaller than 5 cm2. This work demonstrated that, using the ATR-FT-IR imaging method, it is possible to measure and directly compare the transdermal processes of several permeants under identical conditions.

Keywords: ATR-FT-IR IMAGING; ATTENUATED TOTAL REFLECTION; DIFFUSION; DRUGS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HIGH THROUGHPUT; HUMAN SKIN; IMAGING; STRATUM CORNEUM

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370209788347011

Affiliations: Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom

Publication date: May 1, 2009

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