If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Using Micro-Attenuated Total Reflection Spectroscopy to Determine Chemically Induced Changes in Neat Human Hair: Feasibility Study on the Effect of Antipsychotic Drugs

$29.00 plus tax (Refund Policy)

Buy Article:


This investigation examines the feasibility of detecting changes in intact human hair upon drug exposure using diamond attenuated total reflection (ATR) infrared spectroscopy. Prior work on microtomed hair has reported spectra changes in the medulla of the hair resulting from drug exposure. This study focuses on examining the hair intact, eliminating sample preparation and thereby reducing the possibility of sample contamination. Several hair samples were first examined to determine whether the lipids in the medulla could be detected from intact hair. Once this was established, hair samples exposed to drugs were investigated to see if changes in those lipids could be detected. Both internal and external drug exposures were investigated: hair samples were externally (incorporated) exposed to Clozapine and real-life samples were obtained from a patient on alprazolam (Xanax). In both cases, spectral differences in the C–H bands were observed in the hairs with drug exposure as compared to hair with no known drug exposure. These changes are consistent with changes in the lipids in the medulla.


Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370208784909445

Affiliations: 1: John Jay College of Criminal Justice, The City University of New York, Department of Sciences, 445 W 59th Street, New York, New York 10019 2: Harrick Scientific Products, Inc. 141 Tompkins Ave, 2nd floor PO Box 277, Pleasantville, New York 10570

Publication date: July 1, 2008

More about this publication?
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more