Characterization of the Ag Mediated Surface-Enhanced Raman Spectroscopy of Saxitoxin

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Abstract:

The rapid detection and quantification of saxitoxin (STX) is reported using surface-enhanced Raman spectroscopy (SERS) with a colloidal hydrosol of silver nanoparticles. Under the conditions of our experiments, the limit of detection (L D) for STX using SERS is 3 nM, with a limit of quantification (L Q) of 20 nM. It is shown that the SERS method is rapid, with spectra being collected in as little as 5 seconds total integration time for a 40 nM STX sample. In order to improve the signal-to-noise ratio, SERS spectra were generally collected with a total integration time of 1 minute (6 accumulations of 10 seconds each), with no need for extensive sample work-up or substrate preparation. Based on these results, the SERS technique shows great promise for the future detection and quantification of STX molecules in aqueous solutions.

Keywords: HARMFUL ALGAL BLOOM TOXIN; PARALYTIC SHELLFISH POISON; PSP; SAXITOXIN; SERS; SILVER COLLOID; STX; SURFACE-ENHANCED RAMAN SPECTROSCOPY

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370208784909580

Affiliations: 1: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208 2: Food and Drug Administration, HFS-716, CHCB DBC ORS CFSAN, College Park, Maryland 20740

Publication date: July 1, 2008

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