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Rapid Nondestructive On-Site Screening of Methylamphetamine Seizures by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy

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Abstract:

The identification and quantification of illicit substances in the field is often desirable. Fourier transform infrared spectroscopy (FT-IR) has both qualitative and quantitative capabilities and field portable instruments are commercially available. Transmission infrared spectra of mixtures containing ephedrine hydrochloride, glucose, and caffeine and attenuated total reflection (ATR) infrared spectra of mixtures composed of methylamphetamine hydrochloride, glucose, and caffeine were used to develop principal component regression (PCR) calibration models. The root mean sum of errors of predictions (RMSEP) of all individual components in a mixture from a single measurement was <6% w/w, which reduced to ∼3% w/w when triplicates were averaged. Sample mixing and grinding are essential to minimize the effect of heterogeneity, as deviations of up to 20% w/w were observed for single measurements of unground samples. Poor predictions of the components in a mixture occurred when samples were "contaminated" with substances not present in the calibration set, as would be expected. When only a single analyte (drug) was targeted, using a calibration set that contained both contaminated and uncontaminated samples, an RMSEP of ∼4% w/w was achieved. The results demonstrate that ATR-FT-IR has the potential to quantify methylamphetamine samples, and possibly other licit or illicit substances, in at-seizure and on-site scenarios.

Keywords: ATR; ATTENUATED TOTAL REFLECTION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FT-IR SPECTROSCOPY; INFRARED SPECTROSCOPY; METHYLAMPHETAMINE; QUANTITATIVE ANALYSIS; RAMAN SPECTROSCOPY

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370208784658002

Affiliations: 1: Department of Applied Chemistry, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia 2: Forensic Science Laboratory, Chemistry Centre (Western Australia), 125 Hay Street, East Perth, WA 6004, Australia

Publication date: June 1, 2008

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