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Fiber-Optic Infrared Reflection Absorption Spectroscopy for Trace Analysis on Surfaces of Varying Roughness. Part II: Acetaminophen on Stainless Steel

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Abstract:

Investigations of the effects of surface roughness on the utility of grazing-angle Fourier transform infrared reflection absorption spectroscopy (IRRAS) as a method for quantifying trace contamination of metal surfaces have been extended to acetaminophen, a model active pharmaceutical agent, on 316 stainless steel. The effects are more complicated than for the surfactant sodium dodecyl sulfate (SDS) on stainless steel; they include a strong surface-finish dependence of sensitivity and nonlinear behavior at surface loadings above ∼1–2 μg cm−2. Using data from samples in the loading range 0–0.5 μg cm−2, unbiased partial least squared calibrations can be readily achieved for individual surface finishes with detection limits of LD ≈ 0.15 μg cm−2. However, as found for SDS on stainless steel, models built using data from samples of mixed surface roughness are more problematic.

Keywords: CHEMOMETRIC ANALYSIS; GRAZING ANGLE FT-IRRAS; INFRARED REFLECTION ABSORPTION SPECTROSCOPY; IRRAS; ROUGH SURFACES; STAINLESS STEEL; SURFACE CLEANLINESS VALIDATION; TRACE ACTIVE PHARMACEUTICAL AGENT

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370208783759731

Affiliations: 1: Department of Chemistry, University of Canterbury, Christchurch, New Zealand 2: Remspec Corporation, Sturbridge, Massachusetts 01507

Publication date: March 1, 2008

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