Quantitative Nondestructive Methods for the Determination of Ticlopidine in Tablets Using Reflectance Near-Infrared and Fourier Transform Raman Spectroscopy

$29.00 plus tax (Refund Policy)

Buy Article:

Abstract:

Two different nondestructive spectroscopy methods based on near-infrared (NIR) and Fourier transform (FT) Raman spectroscopy were developed for the determination of ticlopidine-hydrochloride (TCL) in pharmaceutical formulations and the results were compared to those obtained by high-performance liquid chromatography (HPLC). An NIR assay was performed by reflectance over the 850–1700 nm region using a partial least squares (PLS) prediction model, while the absolute FT-Raman intensity of TCL's most intense vibration was used for constructing the calibration curve. For both methodologies the spectra were obtained from the as-received film-coated tablets of TCL. The two quantitative techniques were built using five "manual compressed" tablets containing different concentrations and validated by evaluating the calibration model as well as the accuracy and precision. The models were applied to commercial preparations (Ticlid®). The results were compared to those obtained from the application of HPLC using the methodology described by "Sanofi Research Department" and were found to be in excellent agreement, proving that NIR, using fiber-optic probes, and FT-Raman spectroscopy can be used for the fast and reliable determination of the major component in pharmaceutical analysis.

Keywords: FOURIER TRANSFORM RAMAN SPECTROSCOPY; FT-RAMAN SPECTROSCOPY; NEAR-INFRARED SPECTROSCOPY; QUANTITATIVE ANALYSIS; TABLETS; TICLOPIDINE-HCL

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370208783575636

Affiliations: 1: Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotelian University of Thessaloniki, 54124 Thessaloniki, Greece 2: Department of Pharmacy, University of Patras, Greece; Institute of Chemical Engineering and High Temperature Chemical Processes, FORTH, P.O. Box 1414, GR-26504, Patras, Greece

Publication date: February 1, 2008

More about this publication?
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more