Authors: Markopoulou, C.K.¹; Koundourellis, J.E.¹; Orkoula, M.G.²; Kontoyannis, C.G.²

Source: Applied Spectroscopy, Volume 62, Issue 2, Pages 32A-72A and 133-257 (February 2008) , pp. 251-257(7)

Publisher: Society for Applied Spectroscopy

Abstract:

Two different nondestructive spectroscopy methods based on near-infrared (NIR) and Fourier transform (FT) Raman spectroscopy were developed for the determination of ticlopidine-hydrochloride (TCL) in pharmaceutical formulations and the results were compared to those obtained by high-performance liquid chromatography (HPLC). An NIR assay was performed by reflectance over the 850-1700 nm region using a partial least squares (PLS) prediction model, while the absolute FT-Raman intensity of TCL's most intense vibration was used for constructing the calibration curve. For both methodologies the spectra were obtained from the as-received film-coated tablets of TCL. The two quantitative techniques were built using five "manual compressed" tablets containing different concentrations and validated by evaluating the calibration model as well as the accuracy and precision. The models were applied to commercial preparations (Ticlid^®). The results were compared to those obtained from the application of HPLC using the methodology described by "Sanofi Research Department" and were found to be in excellent agreement, proving that NIR, using fiber-optic probes, and FT-Raman spectroscopy can be used for the fast and reliable determination of the major component in pharmaceutical analysis.

Keywords: QUANTITATIVE ANALYSIS; NEAR-INFRARED SPECTROSCOPY; FOURIER TRANSFORM RAMAN SPECTROSCOPY; FT-RAMAN SPECTROSCOPY; TICLOPIDINE-HCL; TABLETS

Document Type: Research article

DOI: http://dx.doi.org/10.1366/000370208783575636

Affiliations: 1: Laboratory of Pharmaceutical Analysis, School of Pharmacy, Aristotelian University of Thessaloniki, 54124 Thessaloniki, Greece 2: Department of Pharmacy, University of Patras, Greece; Institute of Chemical Engineering and High Temperature Chemical Processes, FORTH, P.O. Box 1414, GR-26504, Patras, Greece

Publication date: 2008-02-01

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