Authors: Eliasson, C.¹; Claybourn, M.²; Matousek, P.¹

Source: Applied Spectroscopy, Volume 61, Issue 10, Pages 218A-242A and 1025-1133 (October 2007) , pp. 1123-1127(5)

Publisher: Society for Applied Spectroscopy

Abstract:

A simple procedure for the recovery of deep subsurface Raman spectra in stratified turbid samples by defocusing a conventional Raman instrument is presented. The method is based on effects present with spatially offset Raman spectroscopy (SORS) and, although not as efficient as the standard SORS approach, it permits a simple way of recovering subsurface Raman spectra from less challenging samples. Demonstration of the effect is performed using a standard SORS device and a commercial Raman instrument on the noninvasive measurement of paracetamol tablets held within a nontransparent white plastic bottle.

Keywords: SPATIALLY OFFSET RAMAN SPECTROSCOPY; SORS; RAMAN SPECTROSCOPY; DIFFUSE SCATTERING; TURBID MEDIA; PHARMACEUTICAL PRODUCTS

Document Type: Research article

DOI: http://dx.doi.org/10.1366/000370207782217770

Affiliations: 1: Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, United Kingdom 2: AstraZeneca, Silk Road Business Park, Charter Way, Macclesfield, SK10 2NA, United Kingdom

Publication date: 2007-10-01

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