Deep Subsurface Raman Spectroscopy of Turbid Media by a Defocused Collection System

Authors: Eliasson, C.1; Claybourn, M.2; Matousek, P.1

Source: Applied Spectroscopy, Volume 61, Issue 10, Pages 218A-242A and 1025-1133 (October 2007) , pp. 1123-1127(5)

Publisher: Society for Applied Spectroscopy

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

A simple procedure for the recovery of deep subsurface Raman spectra in stratified turbid samples by defocusing a conventional Raman instrument is presented. The method is based on effects present with spatially offset Raman spectroscopy (SORS) and, although not as efficient as the standard SORS approach, it permits a simple way of recovering subsurface Raman spectra from less challenging samples. Demonstration of the effect is performed using a standard SORS device and a commercial Raman instrument on the noninvasive measurement of paracetamol tablets held within a nontransparent white plastic bottle.

Keywords: SPATIALLY OFFSET RAMAN SPECTROSCOPY; SORS; RAMAN SPECTROSCOPY; DIFFUSE SCATTERING; TURBID MEDIA; PHARMACEUTICAL PRODUCTS

Document Type: Research article

DOI: 10.1366/000370207782217770

Affiliations: 1: Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0QX, United Kingdom 2: AstraZeneca, Silk Road Business Park, Charter Way, Macclesfield, SK10 2NA, United Kingdom

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$29.00 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A