Authors: Pelletier, M.J.¹; Fabiilli, M.L.¹; Moon, Brian²

Source: Applied Spectroscopy, Volume 61, Issue 10, Pages 218A-242A and 1025-1133 (October 2007) , pp. 1107-1115(9)

Publisher: Society for Applied Spectroscopy

Abstract:

We describe the use of an on-line Raman analyzer to quantitatively track the levels of trans-stilbene, benzaldehyde, and α-methoxybenzyl hydroperoxide in a continuous flow ozonolysis reactor. Quantitative analysis is carried out using spectral stripping in order to overcome baseline artifacts inherent in simple peak area determinations and to incorporate prior knowledge into the analytical model. The performance of spectral stripping is compared to partial least squares (PLS) analysis. The effect of two process variables, feed flow rate and ozone concentration, are also explored. Finally, the benefit of utilizing an on-line technique is illustrated by demonstrating the bias introduced by sampling for off-line analysis.

Keywords: RAMAN; QUANTITATIVE ANALYSIS; OZONOLYSIS; TRANS-STILBENE; BENZALDEHYDE; ALPHA-METHOXYBENZYL HYDROPEROXIDE; SPECTRAL STRIPPING; PARTIAL LEAST SQUARES; PLS

Document Type: Research article

DOI: http://dx.doi.org/10.1366/000370207782217725

Affiliations: 1: Research Analytical, Pharmaceutical Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105 2: Development API, Pharmaceutical Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publication date: 2007-10-01

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