Coded Aperture Raman Spectroscopy for Quantitative Measurements of Ethanol in a Tissue Phantom
Authors: McCain, S.T.1; Gehm, M.E.1; Wang, Y.1; Pitsianis, N.P.1; Brady, D.J.1
Source: Applied Spectroscopy, Volume 60, Issue 6, Pages 154A-168A and 573-712 (June 2006) , pp. 663-671(9)
Publisher: Society for Applied Spectroscopy
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Abstract:
Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r2 > 0.98. Leave-one-out cross-validation demonstrates prediction errors of, <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.Keywords: RAMAN SPECTROSCOPY; MULTIPLEXING; CHEMOMETRICS
Document Type: Research article
DOI: 10.1366/000370206777670693
Affiliations: 1: Department of Electrical and Computer Engineering and the Fitzpatrick Institute for Photonics, Duke University, Durham, North Carolina 27708
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