Skip to main content

Coded Aperture Raman Spectroscopy for Quantitative Measurements of Ethanol in a Tissue Phantom

Buy Article:

$29.00 plus tax (Refund Policy)

Abstract:

Coded aperture spectroscopy allows for sources of large ├ętendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r 2 > 0.98. Leave-one-out cross-validation demonstrates prediction errors of, <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.

Keywords: CHEMOMETRICS; MULTIPLEXING; RAMAN SPECTROSCOPY

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370206777670693

Affiliations: Department of Electrical and Computer Engineering and the Fitzpatrick Institute for Photonics, Duke University, Durham, North Carolina 27708

Publication date: June 1, 2006

More about this publication?
sas/sas/2006/00000060/00000006/art00015
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more