If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Determination of Active Pharmaceutical Ingredients by Heteroatom Selective Detection Using Inductively Coupled Plasma Mass Spectrometry with Ultrasonic Nebuilization and Membrane Desolvation Sample Introduction

$29.00 plus tax (Refund Policy)

Buy Article:

Abstract:

The combination of ultrasonic nebulization with membrane desolvation (USN-MD) is utilized to determine active pharmaceutical ingredients (API) by heteroatom inductively coupled mass spectroscopy (ICP-MS) detection. Ultrasonic nebulization provides efficient sampling while use of the membrane desolvator acts to reduce solvent-based interferences. This approach reduces interferences sufficiently so that a standard argon ICP-quadrupole MS can be utilized. Examined APIs and associated heteroatoms included: phosphomycin (P), amoxicillin (S), chlorpropamide (Cl), and ofloxacin (F). The optimum plasma r.f. powers for P, S, and Cl were in the 1000 to 1200 watts range. The high ionization energy of F required that the plasma be operated at 1500 W. The 16O2 + interference at mass 32 precluded determinations using the sulfur-32. The sulfur-34 (4.2% natural isotopic abundance), however, was relatively free of isobaric interferences. Interferences were relatively small at the mass 35 isotope of Cl, but increased with higher ICP r.f. powers. Overlaps were significant at the masses of monoisotopic species, fluorine-19 and phosphorus-31. Detection limits for P, S, Cl, and F of 2, 3, 90, and 3000 ng/mL, respectively, were generally lower than those produced with other quadrupole systems and comparable to or better than values published utilizing high-resolution instruments.

Keywords: DIRECT SOLUTION INTRODUCTION; ELEMENTAL ANALYSIS; HETEROATOM DETERMINATION; ICP-MS; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; MEMBRANE DESOLVATION; PHARMACEUTICAL; ULTRASONIC NEBULIZATION; USN-MD

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370206775382659

Affiliations: 1: Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115 2: Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105

Publication date: January 1, 2006

More about this publication?
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more