Red-Excitation Dispersive Raman Spectroscopy is a Suitable Technique for Solid-State Analysis of Respirable Pharmaceutical Powders

Author: Vehring, Reinhard

Source: Applied Spectroscopy, Volume 59, Issue 3, Pages 267-391 and 62A-72A (March 2005) , pp. 286-292(7)

Publisher: Society for Applied Spectroscopy

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Abstract:

Dispersive Raman spectroscopy with excitation by a red diode laser is suitable for quantitative crystallinity measurements in powders for pulmonary drug delivery. In spray-dried mixtures of salmon calcitonin and mannitol, all three crystalline polymorphs of mannitol and amorphous mannitol were unambiguously identified and their mass fractions were measured with a limit of quantification of about 5%. The instrument design offered high sensitivity and adequate background suppression, resulting in a low limit of detection in the range of 0.01% to 1%. This spectroscopy method has significant advantages over established techniques regarding specificity, sensitivity, and sample requirements.

Keywords: CRYSTALLINITY MEASUREMENTS; DISPERSIVE RAMAN SPECTROSCOPY; MORPHOLOGY EFFECTS; POLYMORPHISM; PROTEINS; QUANTIFICATION; SACCHARIDES

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702053585318

Affiliations: Nektar Therapeutics, 150 Industrial Rd., San Carlos, California 94070

Publication date: March 1, 2005

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