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Microscopic Infrared Mapping of Chloromethylated Polystyrene Resin Beads

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In solid-phase combinatorial chemistry, analyses are performed using a wide range of analytical techniques ranging from gel-phase nuclear magnetic resonance (NMR) to colorimetric tests to elemental analysis. However, these techniques cannot be used to interrogate functional group distribution at the single-bead level. This paper explores the feasibility of using Fourier transform infrared (FT-IR) microscopy to examine site distribution on chloromethylated polystyrene resin beads and to quantify the loading after coupling with 4-cyanophenol, an IR tagging agent. FT-IR microscopy also provides a unique opportunity to better understand the reactivity of highly cross-linked polymer beads under a range of chemical conditions.

Keywords: Chloromethylated polystyrene; Combinatorial chemistry; FT-IR microscopy; Fourier transform infrared microscopy; Site distribution; Solid-phase synthesis

Document Type: Research Article


Affiliations: Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom

Publication date: November 1, 2004

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