Quantitative Analysis of Vitamin A Degradation by Raman Spectroscopy

Authors: Failloux, Nelly; Bonnet, Isabelle; Baron, Marie-Hélène; Perrier, Eric

Source: Applied Spectroscopy, Volume 57, Issue 9, Pages 259A-279A and 1053-1199 (September 2003) , pp. 1117-1122(6)

Publisher: Society for Applied Spectroscopy

Key:

- Free Content

- New Content

- Subscribed Content

- Free Trial Content

Abstract:

Vitamin A is known to support cell growth promotion, maintenance, and differentiation of epithelial tissues. Retinol is currently used in cosmetic formulations and products to deliver these and other benefits to the skin. However, retinol is known to be unstable and, therefore, remains of great concern to the cosmetic industry. The decomposition pathways of the retinoids in general have been previously postulated and investigated mostly by high-performance liquid chromatography (HPLC) with UV/Vis spectroscopy. In our studies, we examined specific conditions at which retinol degrades and subsequently identified and quantified the products of retinol decomposition by Raman spectroscopy. We reveal which experimental settings and computational tools allow monitoring of in situ evolution of an all-trans retinol solution when submitted to UV light in the presence of oxygen.

Keywords: ALL-TRANS RETINOL; UV LIGHT; RAMAN SPECTROSCOPY; QUANTIFICATION

Document Type: Research article

DOI: 10.1366/00037020360695973

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$29.00 plus tax Refund Policy