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Flow-Through Picoliter Dispenser: A New Approach for Solvent Elimination in FT-IR Spectroscopy

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Abstract:

A new interface for FT-IR analysis of liquid samples on the basis of solvent elimination is presented. The approach is based on a piezoactuated flow-through microdispenser, a device built of two microstructured silicon wafers designed for micro-liquid handling. It could be verified during preliminary studies using a sequential injection (SI) system for automated liquid handling that the flow-through microdispenser as a possible interface for flow system-FT-IR analysis has the capability of meeting the demands of hyphenated miniaturized liquid handling systems (e.g., μ-HPLC, micro-high performance liquid chromatography), as it successfully provides highly stable, reliable and reproducible operating conditions for liquid handling in the picoliter range. Moreover, an increase in sensitivity for FT-IR measurements could be achieved, lowering the mass detection limit of sugars (such as the investigated sucrose) to 53 picograms. As is demonstrated on the example of an HPLC separation of a mixture of glucose and fructose, interfacing LC systems to FT-IR using a piezoactuated flow-through microdispenser is a feasible and promising approach.

Keywords: FLOW-THROUGH MICRODISPENSER; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FT-IR; MICRO-LIQUID HANDLING; SOLVENT ELIMINATION

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370202760171581

Publication date: July 1, 2002

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