Multinuclear Magnetic Resonance Spectroscopy of Human Healthy and Neoplastic Renal Tissues
Abstract:High-resolution multinuclear magnetic resonance spectroscopy (MRS) (1H, 13C, and 31P) has been applied for the first time to the study of the biochemical composition of human healthy and neoplastic renal tissues. Thirteen healthy renal tissues, thirteen renal cell carcinomas, and five oncocytomas were examined. From each sample two types of extract were obtained: the water-soluble fraction and the lipid fraction. 1H MRS of aqueous extracts yielded information on renal osmolytes which can be considered markers of physiological renal function. The decrease or the disappearance of these osmolytes and the appearance of glycine in renal cell carcinomas is a hallmark of cancer. The oncocytomas, benign tumors, appear to have a biochemical composition in between healthy and malignant tissue. Further information can be derived from the 13C MR analysis of the lipid fraction: cholesteryl esters, present in high amounts in renal cell carcinomas, are related to the vascularization degree of the tumor. Other correlations between the spectroscopic results and the histopathological data are reported.
Document Type: Research Article
Publication date: July 1, 2001
More about this publication?
- The Society publishes the internationally recognized, peer reviewed journal, Applied Spectroscopy, which is available both in print and online. Subscriptions are included with membership or can be purchased by institutional or corporate organizations. Abstracts may be viewed free of charge. Previously published as Bulletin (Society for Applied Spectroscopy)
- Editorial Board
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Membership Information
- Request copyrighted SAS materials
- Spectroscopic Nomenclature
- Focal Point (Open Access)
- ingentaconnect is not responsible for the content or availability of external websites