Implementation of Raman Spectroscopy as an Analytical Tool throughout the Synthesis of Solid-Phase Scaffolds

Authors: Pivonka, Don E.; Sparks, Richard B.

Source: Applied Spectroscopy, Volume 54, Issue 11, Pages 373A-385A and 1549-1718 (November 2000) , pp. 1584-1590(7)

Publisher: Society for Applied Spectroscopy

Buy & download fulltext article:

Price: $29.00 plus tax (Refund Policy)

Abstract:

Raman spectroscopy has been implemented as an extremely powerful tool for the vibrational analysis of solid-phase synthesis. In this report, the application of both on-line and batch-mode Raman analysis is presented for the comprehensive characterization of a multi-step small-molecule synthesis. Throughout this application, near-infrared Raman spectroscopy also provides unprecedented utility for on-bead qualitative and quantitative investigations. Finally, the on-line experimental procedure presents the first opportunity for open-loop feedback control of solid-phase synthetic parameters through the real-time presentation of reaction progression using Raman spectroscopy.

Keywords: RAMAN; SPECTROSCOPY; ON-LINE; ANALYSIS; COMBINATORIAL; CHEMISTRY

Document Type: Research article

DOI: http://dx.doi.org/10.1366/0003702001948835

Affiliations: 1: AstraZeneca Pharmaceuticals, A Business Unit of Zeneca Inc., 1800 Concord Pike, Wilmington, Delaware 19850

Publication date: 2000-11-01

More about this publication?

The Society publishes the internationally recognized, peer reviewed journal, Applied Spectroscopy, which is available both in print and online. Subscriptions are included with membership or can be purchased by institutional or corporate organizations. Abstracts may be viewed free of charge.

Previously published as Bulletin (Society for Applied Spectroscopy)
Editorial Board
Information for Authors
Submit a Paper
Subscribe to this Title
Membership Information
Request copyrighted SAS materials
Spectroscopic Nomenclature
Focus Compendium
ingentaconnect is not responsible for the content or availability of external websites