Near-Infrared Spectroscopic Measurement of Lactate in Human Plasma

Authors: LaFrance, Denis; Lands, Larry C.; Hornby, Laura; Burns, David H.

Source: Applied Spectroscopy, Volume 54, Issue 2, Pages 52A-77A and 159-330 (February 2000) , pp. 300-304(5)

Publisher: Society for Applied Spectroscopy

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Abstract:

A method based on near-infrared spectroscopy (NIRS) is presented, which provides a rapid analysis of lactate in plasma. In order to test the technique, NIRS analysis and enzymatic measurements were made on plasma samples taken from exercising humans. A correlation coefficient of 0.995 and a standard error of 0.51 mmol/L were found between the enzymatic and the NIR results. This standard error is within the range needed for real-time monitoring of lactate in plasma for exercising studies. In the future, this technique may provide a valuable tool to assess physiological status for research and clinical use.

Keywords: LACTATE; NEAR-INFRARED SPECTROSCOPY; PARTIAL LEAST-SQUARES REGRESSION ANALYSIS; ENZYMATIC METHOD; CHEMOMETRIC TECHNIQUES; IN VITRO SERUM ANALYSIS

Document Type: Research article

DOI: http://dx.doi.org/10.1366/0003702001949267

Publication date: 2000-02-01

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