If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Infrared Investigation of Acid Activation by PyBOP in Polystyrene/Divinylbenzene Supported Solid-Phase Synthesis

$29.00 plus tax (Refund Policy)

Buy Article:


The infrared technology presented in this paper provides a mechanism for the detailed study of PyBOP [(1H-benzotriazole-1- yloxy)tripyrrolidinophosphonium hexafluorophosphate] ester activation in a solid-phase supported chemical system. Prior to this work, formation of the alkoxyphosphonium salt had been postulated as a necessary reactive intermediate for formation of the triazoleactivated ester in the PyBOP activation process; however, observation of the alkoxyphosphonium salt has not been reported at room temperature. The present work not only confirms the presence of the salt but further demonstrates it to be the primary activated species for couplings performed on the solid phase at room temperature. More important than the specific identification of the PyBOP activation method is the general introduction of a set of infrared analytical tools for analysis of solid-phase reaction mechanisms and kinetics.


Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702991947955

Publication date: September 1, 1999

More about this publication?
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more