NMR Diffusion and Relaxation Study on Ibuprofen-HSA Interaction

$29.00 plus tax (Refund Policy)

Buy Article:


NMR diffusion and relaxation measurements were applied to study the ibuprofen-protein interaction by changing the drug concentration in solutions containing 0.1 M human serum albumin (HSA). On the basis of the assumption that the drug molecules undergo fast exchange between the binding and free states, the association constant, Ka, for drug-HSA complexes is found to be about 60, and the number of binding sites, n, is about 50. The small association constant and the big binding site number suggest weak interactions between ibuprofen and HAS.


Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702991947559

Publication date: July 1, 1999

More about this publication?
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more