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Research Strategy for the HPLC/FT-IR Analysis of Drug Metabolites

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Abstract:

A strategy for the infrared spectroscopic analysis of drug metabolites in high-pressure liquid chromatography (HPLC) effluent is presented with a primary focus on delivery of metabolite structure as opposed to development of dedicated or automated instrumentation. This paper stresses the complementary nature of on-line (solution phase) and off-line (condensed phase) HPLC Fourier transform infrared (FT-IR) implementations for structural elucidation of drug metabolites.

Keywords: HYPHENATED TECHNIQUES ON-LINE

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702971941151

Publication date: June 1, 1997

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sas/sas/1997/00000051/00000006/art00016
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