Spectrofluorimetric Study of the Inclusion Complex of 7-Hydroxymethylnalidixic Acid with gamma-Cyclodextrin in Aqueous Solution

$29.00 plus tax (Refund Policy)

Buy Article:

Abstract:

A fluorimetric study on the spectral characteristics and acid-base behavior of 7-hydroxymethylnalidixic acid has been performed. The host-guest complexation process between gamma -cyclodextrin and 7-hydroxymethylnalidixic acid has also been investigated by fluorescence spectroscopy. Scatchard and Benesi-Hildebrand methods have been applied to determine the stoichiometry of the complex, and a 1:1 stoichiometric ratio has been established. A K1 = 118 +/- 25 M -1 formation constant has been calculated for the inclusion complex, by using the changes produced on the fluorescence of 7-hydroxymethylnalidixic acid, when it is included on the hydrophobic cyclodextrin cavity. A fluorimetric method of determination of 7-hydroxymethylnalidixic acid, in gamma -cyclodextrin aqueous solution, has been proposed. The analytical parameters and detection and quantification limits of the method have been determined.

Keywords: HYDROXYMETHYLNALIDIXIC ACID GAMMA-CYCLODEXTRIN SPECTROFLUORIMETRY

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702971940828

Publication date: May 1, 1997

More about this publication?
Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more