Provider: ingentaconnect
Database: ingentaconnect
Content: application/x-research-info-systems
TY - ABST
AU - Chiang, Ping
AU - Li, Kuang-Pang
AU - Hseu, Tong-Ming
TI - Spectrochemical Behavior of Carcinogenic Polycyclic Aromatic Hydrocarbons in Biological Systems. Part II: A Theoretical Rate Model for BaP Metabolism in Living Cells
JO - Applied Spectroscopy
PY - 1996-11-01T00:00:00///
VL - 50
IS - 11
SP - 1352
EP - 1359
KW - Polycyclic aromatic hydrocarbons
KW - Benzo[a]pyrene
KW - Metabolism
KW - Living cells
N2 - An idealized model for the kinetics of benzo[*a*]pyrene (BaP) metabolism is established. As observed from experimental results, the BaP transfer from microcrystals to the cell membrane is definitely a first-order process. The rate constant of this process is signified as *k*
_{1}.
We describe the surface-midplane exchange as reversible and use rate constants *k*
_{2} and *k*
_{3} to describe the inward and outward diffusions, respectively. The metabolism is identified as an irreversible reaction with a rate constant *k*
_{4}. If *k*
_{2}
and *k*
_{3} are assumed to be fast and not rate determining, the effect of the metabolism rate, *k*
_{4}, on the number density of BaP in the midplane of the microsomal membrane, *m*
_{3}, can be estimated. If the metabolism rate is faster than or comparable
to the distribution rates, *k*
_{2} and *k*
_{3}, the BaP concentration in the membrane midplane, *m*
_{3}, will quickly be dissipated. But if *k*
_{4} is extremely small, *m*
_{3} will reach a plateau. Under conditions when *k*
_{2}
and *k*
_{3} also play significant roles in determining the overall rate, more complicated patterns of *m*
_{3} are expected.
UR - http://www.ingentaconnect.com/content/sas/sas/1996/00000050/00000011/art00004
M3 - doi:10.1366/0003702963904782
UR - http://dx.doi.org/10.1366/0003702963904782
ER -