Use of Shift Reagents to Determine Enantiomers by Near-Infrared Analysis
Abstract:A method is described that utilizes β-cyclodextrin and silica gel as shift reagents to distinguish between enantiomers by means of near-infrared transmission spectroscopy. The premise is that the spectrum of the (+)-enantiomer bound to the shift reagent will be different from that of the (−)-enantiomer bound to the same reagent. With the use of principal component analysis, the difference between the enantiomers can be distinguished. The resulting method is fast, simple, and of potential application in pharmaceutical process control.
Document Type: Research Article
Affiliations: Department of Chemistry, Indiana University, Bloomington, Indiana 47405
Publication date: September 1, 1996
More about this publication?
- The Society publishes the internationally recognized, peer reviewed journal, Applied Spectroscopy, which is available both in print and online. Subscriptions are included with membership or can be purchased by institutional or corporate organizations. Abstracts may be viewed free of charge. Previously published as Bulletin (Society for Applied Spectroscopy)
- Editorial Board
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Membership Information
- Request copyrighted SAS materials
- Spectroscopic Nomenclature
- Focal Point (Open Access)
- ingentaconnect is not responsible for the content or availability of external websites