Spectroscopic and Thermoanalytical Characterization of (+)-Fenfluramine Hydrochloride

$29.00 plus tax (Refund Policy)

Buy Article:


We have analyzed the vibrational, structural, and thermal properties of a pure enantiomer of fenfluramine. At room temperature the samples, as-received or ground, are in the α-phase, in which hydrogen bonds are formed among adjacent molecules. Evidence of these H bonds is no longer found in samples which have been annealed above a critical temperature. Grain size, sample treatment, or defects influence the temperature range where the H bonds break down; this phenomenon is accompanied by thermal effects such as endothermic peaks or anomalies of heat capacity, and followed by a slow structural rearrangement into a γ-phase. No evidence of hydrogen bonds is found in the water recrystallized fenfluramine, which maintains up to the melting temperature a crystallographic form (β-form) distinct from both α- and γ-phases. It is suggested that "folded" and "extended" fenfluramine molecules are characteristic of the α- and β-phase, respectively.

Keywords: (+)-Fenfluramine; Photoacoustic IR spectroscopy; Polymorphism; XRD spectroscopy

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702963905439

Affiliations: 1: Dipartimento di Chimica Fisica dell'Università di Pavia, CSTE, CNR, Viale Taramelli, 16-27100 Pavia, Italy 2: Laboratori MAG, Viale Gran Sasso 22, 20131 Milano, Italy 3: Istituto di Fisica dell'Universita' di Urbino, Via S. Chiara, Urbino, Italy

Publication date: July 1, 1996

More about this publication?
Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more