Effects of Heavy-Atom Salts on the Luminescence Properties of Tetrol I-1 on α-Cyclodextrin/Salt Matrices

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Benzo(a)pyrene [B(a)P] is one of the most widely studied polyaromatic hydrocarbons. In the human body and in lower animals, B(a)P can become chemically bonded to DNA. Tetrols are the products obtained from the hydrolysis of B(a)P-DNA adducts. It has been proposed that the amount of tetrols detected in human body fluids can be used as a measure of the amount of B(a)P-DNA adducts present in the body. The effects of several heavy-atom salts on the solid-matrix fluorescence and phosphorescence properties of the tetrols were investigated. TINO3 and TIF were very useful in enhancing the room-temperature phosphorescence (RTP) of the tetrols. For tetrol I-1 on 1:1:8 α-cyclodextrin:TINO3: NaNO3, the limit of detection was 0.38 femtomole/mg. The RTP approach with the 1:8:α-cyclodextrin:TINO3:NaNO3 matrix would be useful for detecting subfemtomole quantities of the tetrols of B(a)PDNA adducts from biological samples.

Keywords: Benzo(a)pyrene-DNA adduct; Heavy-atom effect; Solid-matrix luminescence; Tetrols

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370294774368884

Affiliations: Department of Chemistry, University of Wyoming, Laramie, Wyoming 82071

Publication date: June 1, 1994

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