Acoustic-resonance spectrometry (ARS) provides a means of identifying and quantifying materials. A new ARS instrument incorporates a three-transducer design that increases sensitivity through interferometry and uses polyvinylidene fluoride piezoelectric films instead of ceramic transducers
to give high output voltages, broader bandwidth, and lower cost. The operating parameters of the ARS are optimized with a widely applicable technique named Universal Numerical Optimization (UNO). The UNO technique allows refinement of instrumental parameters on the basis of distances in hyperspace
between sample sets. The new ARS is able to identify different intact tablets and predict the percent dissolution of intact carbamazepine tablets at one hour in a standard apparatus to within 4.6% at a fraction of the cost of traditional or even near-IR methods.
Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky Medical Center, Lexington, Kentucky 40536-0082
Publication date: April 1, 1994
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The Society publishes the internationally recognized, peer reviewed journal, Applied Spectroscopy, which is available both in print and online. Subscriptions are included with membership or can be purchased by institutional or corporate organizations. Abstracts may be viewed free of charge. Previously published as Bulletin (Society for Applied Spectroscopy)