Skip to main content

Optimization of Acoustic-Resonance Spectrometry for Analysis of Intact Tablets and Prediction of Dissolution Rate

Buy Article:

$29.00 plus tax (Refund Policy)

Abstract:

Acoustic-resonance spectrometry (ARS) provides a means of identifying and quantifying materials. A new ARS instrument incorporates a three-transducer design that increases sensitivity through interferometry and uses polyvinylidene fluoride piezoelectric films instead of ceramic transducers to give high output voltages, broader bandwidth, and lower cost. The operating parameters of the ARS are optimized with a widely applicable technique named Universal Numerical Optimization (UNO). The UNO technique allows refinement of instrumental parameters on the basis of distances in hyperspace between sample sets. The new ARS is able to identify different intact tablets and predict the percent dissolution of intact carbamazepine tablets at one hour in a standard apparatus to within 4.6% at a fraction of the cost of traditional or even near-IR methods.

Keywords: Dissolution test; Optimization; Pharmaceuticals; Ultrasonic

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/000370294775268929

Affiliations: Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky Medical Center, Lexington, Kentucky 40536-0082

Publication date: April 1, 1994

More about this publication?
sas/sas/1994/00000048/00000004/art00015
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more