Spectroscopic Investigations of Malaria Pigment

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Abstract:

Malaria pigment is generated during the growth of the intraerythrocytic parasite plasmodium. This compound is postulated as a product of haemoglobin degradation and consists of an unknown iron porphyrin compound and an apoprotein. We report here a new spectroscopic investigation on the porphyrin component of intact malaria pigment obtained from in vitro cultures of Plasmodium falciparum without any previous chemical or biochemical treatment of the sample. We demonstrate the use of resonance Raman microspectrometry, electron paramagnetic resonance spectrometry, and magnetic susceptibility measurements that show the iron porphyrin moiety of the malaria pigment to be a high-spin monomeric iron(III) protoporphyrin hydroxide.

Keywords: Magnetic measurements; Malaria pigment; Plasmodium falciparum; Resonance Raman spectroscopy

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702934065975

Affiliations: 1: Laboratoire de Spectrochimie Infrarouge et Raman UPR 2631L CNRS, Bât C5 Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq cedex, France 2: Laboratoire de Chimie Inorganique URA 420 CNRS, Université de Paris-Sud, 91405 Orsay, France 3: INSERM U-42 Biologie et Biochimie Parasitaires et Fongiques, 369 rue J. Guesde, 59650 Villeneuve d'Ascq, France; present address: Laboratoire de Biophysique Moléculaire, Université de Bordeaux II 33076 Bordeaux France

Publication date: November 1, 1993

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