Surface-Enhanced Raman Study of Benzylpenicillin

Authors: Reipa, V.1; Horvath, J. J.2

Source: Applied Spectroscopy, Volume 46, Issue 6, Pages 891-1076 (June 1992) , pp. 1009-1013(5)

Publisher: Society for Applied Spectroscopy

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Abstract:

The surface-enhanced Raman spectra (SERS) of benzylpenicillin on electrochemically roughened Ag electrodes were investigated. Spectral assignments were carried out. Comparison with powder Raman spectra demonstrated that the benzene ring is in a vertical position relative to the surface. The molecule is bonded to the silver surface through the carboxylate group and the tertiary nitrogen of the beta-lactam ring, resulting in formation of a bidentate surface complex. Evidence of partial benzylpenicillin hydrolysis into 6-aminopenicillanic acid and phenylacetic acid on the surface of the electrode is presented. No indication of electrochemical reactions was observed in the potential range from −1.2 to +0.3 V.

Keywords: Adsorption; Benzylpenicillin; Silver electrode; Surface-enhanced Raman spectroscopy

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702924124501

Affiliations: 1: Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899; on leave from the Institute of Chemistry and Chemical Technology, Vilnius, Lithuania 2: Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899

Publication date: June 1, 1992

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