Topical Protectant Evaluation by FT-IR Spectroscopy

Authors: Braue, Ernest H.1; Pannella, Michael G.2

Source: Applied Spectroscopy, Volume 44, Issue 6, Pages 911-1096 (July 1990) , pp. 1061-1063(3)

Publisher: Society for Applied Spectroscopy

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Abstract:

A unique analytical method for evaluating the effectiveness of topical protectants against penetration by chemical agents has been developed with the use of FT-IR and the horizontal attenuated total reflectance (ATR) accessory. A template was designed which allowed a uniform-thickness layer of topical protectant to be applied to the surface of the ATR crystal. A chemical challenge was applied to the template filled with topical protectant, and spectra were recorded with the use of standard GC software on a Nicolet 60SXB FT-IR spectrometer fitted with an MCT-A detector. Analysis of the recorded spectra identified how much time was required for the chemical challenge to break through the topical protectant barrier. The method was validated with the use of polysaturated fat, petroleum jelly, and hexafluoropropylene epoxide polymer as topical protectants. These materials were challenged with liquid ethyl disulfide. The detection threshold concentration for ethyl disulfide in the topical protectant was observed to be 0.5% (w/w). With a barrier thickness of 0.45 mm, the breakthrough times were observed to be 5.0 min and 22.0 min for polysaturated fat and petroleum jelly. The fluoropolymer showed no breakthrough after 60 min.

Keywords: ATR analysis; Barrier coating evaluation; Infrared spectroscopy; Topical protectants

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702904086759

Affiliations: 1: Basic Assessment Branch, Drug Assessment Division, U.S. Army Medical Research Institute of Chemical Defense, Bldg. E-3081, SGRD-UV-DB, Aberdeen Proving Ground, Maryland 21010-5425 2: Basic Assessment Branch, Drug Assessment Division, U.S. Army Medical Research Institute of Chemical Defense, Bldg. E-3081, SGRD-UV-DB, Aberdeen Proving Ground, Maryland 21010-5425; present address: University of Maryland at Baltimore, School of Pharmacy, Clinical Pharmacokinetics Laboratory, 20 North Pine Street, Baltimore, MD 21201

Publication date: July 1, 1990

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