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Phase-Resolved Fiber-Optics Fluoroimmunosensor

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Abstract:

This paper describes the development and application of a phase-resolved fiber-optics fluoroimmunosensor (PR-FIS), which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiber-optics sensors, and the selectivity of phase-resolved detection. The PR-FIS device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. Benzo(a)pyrene tetrol can be detected at femtomole levels in the presence of an amount of interfacing benzo(a)pyrene that is 50-fold more concentrated.

Keywords: Antibody; DNA adduct; Fiber-optic sensor; Fluorescence; Laser; Phase-resolved spectroscopy

Document Type: Research Article

DOI: http://dx.doi.org/10.1366/0003702904085859

Affiliations: 1: Advanced Monitoring Development Group, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6101 2: Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37916

Publication date: January 1, 1990

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